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Moreover, xCT deficiency produces significant improvements of disease outcomes in MS 28,29 and ALS 27 animal models, suggesting that inhibition of glutamate release via System xc , or another mechanism, would somehow confer neuroprotection

For example, ITC-rich extracts of Moringa oleifera leaf (500 mg/kg administered 30 min prior to tests) induced anxiolytic effects in Swiss mice in lightdark and open field tests (OFT) (137)